Search on: PROTEINS, HOMER 1C 
Descriptors Found: 1
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Descriptor English:   Homer Scaffolding Proteins 
Descriptor Spanish:   Proteínas de Andamiaje Homer 
Descriptor Portuguese:   Proteínas de Arcabouço Homer 
Synonyms English:   Homer 1
Homer 1 Proteins
Homer 1C
Homer 1C Proteins
Homer 1a
Homer 2
Homer 2 Proteins
Homer 3
Homer 3 Proteins
Homer Proteins
Proteins, Homer
Proteins, Homer 1
Proteins, Homer 1C
Proteins, Homer 2
Proteins, Homer 3
Proteins, Homer Scaffolding
Scaffolding Proteins, Homer  
Tree Number:   D12.776.476.024.381
Definition English:   Homer proteins belong to a family of adaptor and scaffold proteins which include Homer1, Homer2 and Homer3. Homer1 and Homer2 play a role in the regulation of calcium homeostasis, whereas Homer3 functions in stimulating changes in actin dynamics in neurons and T-cells. Homer proteins are best known as scaffold proteins at the post-synaptic density where they facilitate synaptic signaling. They function as a molecular switch in metabotropic glutamate receptor (MGluR) signaling, and are associated with human Fragile X syndrome. 
History Note English:   2017 (1997) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   56636 
Unique Identifier:   D000072233 

Occurrence in VHL: 		 

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